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Synthesizing non-natural parts from natural genomic template |
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| Authors: | Pawan K Dhar Chaw Su Thwin Kyaw Tun Yuko Tsumoto Sebastian Maurer-Stroh Frank Eisenhaber Uttam Surana |
| Institution: | (1) Synthetic Biology Lab, RIKEN Advanced Sciences Institute, Yokohama 230-0045, Japan;(2) Biomolecular Function Discovery Division, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, 138673, Singapore;(3) Cell Cycle control Lab, Institute of Molecular and Cellular Biology, 61 Biopolis Drive, 138673, Singapore |
| Abstract: | BackgroundThe current knowledge of genes and proteins comes from 'naturally designed' coding and non-coding regions. It would be interesting to move beyond natural boundaries and make user-defined parts. To explore this possibility we made six non-natural proteins in E. coli. We also studied their potential tertiary structure and phenotypic outcomes. |
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