Studies on the elimination of non-specific inhibitors in sera against influenza viruses with the aid of filtrates ofVibrio cholerae |
| |
Authors: | L M Brans E Hertzberger J L Binkhorst J Mulder |
| |
Institution: | (1) Virus Laboratory of the Clinic of Internal Medicine, University of Leyden, Holland |
| |
Abstract: | Summary In the sera of humans and various animals there are two different non-specific inhibitors (α-and β-inhibitors) which may be
specifically abolished by two substances (α-and β-“enzymes”) both present in filtrates ofV. cholerae. This neutralization is necessary for the rapid classifying of influenza virus strains with the aid of the haemagglutination
inhibition test.
The egg line strains of the A- and A′-groups are only sensitive to β-inhibitor, while the mouse line strains of the same groups
are only sensitive to the α-inhibitor. This does not apply to strains of the B group, where mouse as well as egg lines are
sensitive to both inhibitors.
With the aid of isolated β-inhibitor (easily to be prepared from cattle serum), it is possible to decide in a quick manner
whether or not a strain from the A- or A′-group has previously been adapted to the mouse.
With the technical assistance of Miss I.de Nooyer and with the financial support provided by the Institute for Preventive Medicine, Leyden; N.V. Philips Roxane, Weesp; the
State Department of Science; the Jan Dekker Fund, and the Curacao Fund for Preventive Medicine. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|