Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes. |
| |
| Authors: | P F Blackmore S Mojsov J H Exton J F Habener |
| |
| Institution: | Department of Pharmacology, Eastern Virginia Medical School, Norfolk 23501. |
| |
| Abstract: | The effects of glucagon and the glucagon-like peptide GLP-1(7-37) were compared in rat liver hepatocytes. Glucagon elevated cAMP, elevated intracellular free calcium (Ca2+]i), activated phosphorylase and stimulated gluconeogenesis, whereas GLP-1(7-37) was without effect on any of these parameters. GLP-1(7-37) did not block any of the actions of glucagon. The glucagon analog, des His1Glu9] glucagon amide, was a partial agonist in liver, but also was an effective antagonist of glucagon actions in liver but not those of GLP-1(7-37) in islet B cells. It was concluded that in the rat, GLP-1(7-37) is a potent insulin secretagogue 1] but is without effect on liver. |
| |
| Keywords: | |
|
|
