Studies on the synthesis and properties of new PNA analogs consisting of L- and D-lysine backbones |
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| Authors: | Zhang L Min J Zhang L |
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| Affiliation: | School of Pharmaceutical Sciences, Beijing Medical University, China. |
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| Abstract: | Homopentamers of PNA consisting of L- and D-lysine were synthesized. It was found that the intramolecular hydrogen bonding has no significant influence on intermolecular interaction. These pentamers show a tendency to form complex with polyA in tris(pH 8.0) solution. The L-conformer has more potential than D-isomer. |
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