Membranotropic properties of latrotoxin-like protein: Studies on liposomes |
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| Authors: | I O Trikash Ya T Terletskaya L I Kolchinskaya M K Malysheva |
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| Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine;(2) Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
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| Abstract: | Fusion and changes in permeability of artificial phospholipid vesicles (liposomes) caused by the influence of α-latrotoxin-like
protein (L protein) from the gray matter of the bovine brain were studied using a hydrophobic fluorescent probe, R18. It was
shown that L protein stimulates fusion of negatively charged liposomes. This effect becomes stronger in acidified media. The
influence of L protein on the permeability of phosphatidylcholine liposome membrane is also a pH-dependent process. |
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