New mutations of Nogo-C in hepatocellular carcinoma |
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| Authors: | Chen Yicun Tang Xiaojun Zhang Xiran Zhuang Linyuan |
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| Affiliation: | (1) The Jiangsu Key Laboratory of Molecular and Medical Biotechnology, The College of Life Science, Nanjing Normal University, Nanjing, 210097, P.R. China;(2) Institute of Subtropical Forestry, Chinese Academy of Forestry, Fuyang, 311400, P.R. China;(3) The Gulou Hospital Affiliated to Medical School of Nanjing University, Nanjing, 210008, P.R. China |
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| Abstract: | The neurite outgrowth inhibitor Nogo has attracted great interest, but its relevance with hepatocellular carcinoma has not been reported. This paper first found mutations of Nogo-C in HCC patients from Qidong in China: A172G (Thr58Ala), A340G (Arg114Gly), A571G (Ile191Val). In six examined patient cases from Qidong, the mutations occurred in five cases. The mutation Arg114Gly was predicted bioinformatically to affect Nogo-66 dimensional structure of Nogo-C. Our previous works also had indicated that mutant Nogo-C promoted liver cancer cell line apoptosis and resulted in molecular marker of HCC p53 gene transfer from nucleus to cytoplast. Above results revealed a new physiological role and clinical implications of Nogo-C on HCC. |
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| Keywords: | Nogo-C Hepatocellular carcinoma Point mutation |
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