Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes |
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Authors: | Jyoti Upadhyay Krishna Misra |
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Affiliation: | Indian Institute of Information Technology, Allahabad - 211 002; India |
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Abstract: | Vitamin E is a mixture of eight compounds α, β, γ, δ tocopherols and α, β, γ, δ tocotrienols. Their individual role in cellular transport as antioxidants and in metabolic pathways has been highlighted in the present work. All the eight compounds have been docked with the respective metabolizing enzymes (αtocopherol transfer protein (ATTP), αtocopherol associated protein (TAP), Pglycoprotein (Pgly) and human serum albumin (HSA)) to understand molecular interactions for pharmacokinetics. These have been structurally aligned against the four human phospholipids in order to reveal their individual role in chylomicron formation and hence the mechanism of cellular transport. The study of their binding with their metabolizing enzymes provides insight to the comparative antioxidant activity of each of these isomers. |
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Keywords: | docking data, vitamin E, enzymes, mechanism, anti oxidant |
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