Childhood passive smoke exposure is associated with adult head and neck cancer |
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Authors: | Jesse D Troy Jennifer R Grandis Ada O Youk Brenda Diergaarde Marjorie Romkes Joel L Weissfeld |
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Institution: | 1. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States;2. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States;3. Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States;4. Department of Medicine, Hematology/Oncology Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States;5. University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States |
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Abstract: | Introduction: Passive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain. Methods: We conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only (184 cases and 415 controls). CPSE was also studied in oropharyngeal separately from other HNSCC using polytomous logistic regression. Results: CPSE was associated with HNSCC (OR, 1.28; 95% CI, 1.01–1.63) after controlling for adult smoking and other factors. This association was similar in magnitude, although not statistically significant, among subjects who never smoked as adults (OR, 1.19, 95% CI, 0.80–1.76). CPSE was associated more strongly with oropharyngeal cancer (a HNSCC subtype commonly associated with human papillomavirus (HPV) infection) than with HNSCC at non-oropharyngeal sites (OR, 2.02; 95% CI, 1.01–4.06, N = 52 cases vs. OR, 1.04; 95% CI, 0.68–1.60, N = 132 cases; P-for-heterogeneity = 0.08). Conclusions: Data from this large US-based case control study suggest a role for CPSE in HNSCC etiology. |
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Keywords: | Adolescent Child Head and neck neoplasms Infant Oropharyngeal neoplasms Tobacco smoke pollution |
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