Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study |
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| Authors: | Jessica RB Musselman Michael K Georgieff Julie A Ross Gail E Tomlinson James Feusner Mark Krailo Logan G Spector |
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| Institution: | 1. Department of Pediatrics, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, United States;2. Division of Neonatology, University of Minnesota, Minneapolis, MN 55455, United States;3. Masonic Cancer Research Center, Minneapolis, MN 55455, United States;4. University of Texas Health Science Center, San Antonio, TX 78238, United States;5. Children''s Hospital Oakland Research Institute, Oakland, CA 94609, United States;6. Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, United States |
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| Abstract: | Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR = 1.02; 95% CI 1.00, 1.04 per 1 lb increase and nearly significantly with maternal multivitamin use (OR = 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring. |
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