Computational modeling of paroxysmal depolarization shifts in neurons induced by the glutamate release from astrocytes |
| |
Authors: | Alexander N Silchenko " target="_blank">Peter A Tass |
| |
Institution: | (1) Institute of Neuroscience and Biophysics 3 - Medicine, Research Center Juelich, 52425 Juelich, Germany;(2) Virtual Institute of Neuromodulation, Research Center Juelich, 52425 Juelich, Germany;(3) Institute of Neuromodulation, University of Cologne, 50924 Cologne, Germany;(4) Brain Imaging Center West, Leo-Brandt-Street, 52425 Juelich, Germany |
| |
Abstract: | Recent experimental studies have shown that astrocytes respond to external stimuli with a transient increase of the intracellular
calcium concentration or can exhibit self-sustained spontaneous activity. Both evoked and spontaneous astrocytic calcium oscillations
are accompanied by exocytosis of glutamate caged in astrocytes leading to paroxysmal depolarization shifts (PDS) in neighboring
neurons. Here, we present a simple mathematical model of the interaction between astrocytes and neurons that is able to numerically
reproduce the experimental results concerning the initiation of the PDS. The timing of glutamate release from the astrocyte
is studied by means of a combined modeling of a vesicle cycle and the dynamics of SNARE-proteins. The neuronal slow inward
currents (SICs), induced by the astrocytic glutamate and leading to PDS, are modeled via the activation of presynaptic glutamate
receptors. The dependence of the bidirectional communication between neurons and astrocytes on the concentration of glutamate
transporters is analyzed, as well. Our numerical results are in line with experimental findings showing that astrocyte can
induce synchronous PDSs in neighboring neurons, resulting in a transient synchronous spiking activity. |
| |
Keywords: | Astzocyte Glutamate release Modeling PDS |
本文献已被 PubMed SpringerLink 等数据库收录! |
|