| HIV-1 Tat蛋白神经毒作用的研究进展 |
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| 引用本文： | 滕竞飞,高霄飞.HIV-1 Tat蛋白神经毒作用的研究进展[J].生命科学,2010(1):84-88. |
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| 作者姓名： | 滕竞飞 高霄飞 |
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| 作者单位： | 第二军医大学;第二军医大学神经生物学教研室; |
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| 摘 要： | HIV-1感染者常并发神经系统损伤,患者主要表现为运动功能障碍,认知和行为受损等。研究表明,HIV-1多种蛋白参与上述病理过程,其中Tat蛋白发挥了极为重要的作用。外周Tat蛋白可透过血脑屏障进入脑组织,与脑内感染细胞分泌或释放至胞外的Tat共同作用于NMDAR、mGluR1、多巴胺转运蛋白等,损伤神经系统。该文主要对Tat蛋白的神经毒作用作一综述。
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| 关 键 词： | HIV-1 Tat 血脑屏障 神经毒 |
Progress in study on neurotoxicity of HIV-1 Tat |
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| TENG Jing-fei,GAO Xiao-fei.Progress in study on neurotoxicity of HIV-1 Tat[J].Chinese Bulletin of Life Sciences,2010(1):84-88. |
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| Authors: | TENG Jing-fei GAO Xiao-fei |
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| Institution: | TENG Jing-fei~1,GAO Xiao-fei~(2*) (1 Eight-year-system Clinical Medicine,Second Military Medical University,Shanghai 200433,China,2 Department of Neurobiology,China) |
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| Abstract: | Infection with HIV-1 is always associated with dysfunctions of central nervous system(CNS),the patients are characterized by motor dysfunctions,impaired cognitions and behaviors.Relative researches indicated that,various HIV-1 proteins are responsible for the pathogenesis,among which,Tat is of vital importance. Peripheral Tat,which can cross the blood-brain barrier and infiltrate the brain tissues,as well as that secreted or released from HIV-1-infected cells,can interact with NMDAR,mGluR 1,dopamine transpo... |
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| Keywords: | HIV-1 Tat blood-brain barrier neurotoxicity |
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