Freeze-fracture study of changes in nuclei isolated from ischemic rat kidney |
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| Authors: | S E Coleman J Duggan R L Hackett |
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| Institution: | 1. Research Service, Veterans Administration Hospital Gainesville, Florida 32602 USA;21. Laboratory Service, Veterans Administration Hospital Gainesville, Florida 32602 USA;22. Department of Pathology, University of Florida College of Medicine Gainesville, Florida 32602 USA |
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| Abstract: | The frequency of nuclear pores/μ2 in isolated nuclei from ischemic rat kidneys decreased by half after 20 min of occlusion of the blood supply to the kidney. The decrease in pore number remained constant through 120 min ischemia. Particles in the concave fracture face of the outer nuclear membrane changed from a random distribution in control nuclei to a reticular pattern after 20 min ischemia, becoming more sparse and clustered through 120 min ischemia. Deterioration of the pore structure also was noted after 120 min ischemia. It is suggested that these changes are related to loss of nuclear function. |
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