Fluorometric-colorimetric amino acid analysis of actinomycins using fluorescamine. Mechanism of partial threonine decomposition during acid hydrolysis. |
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| Authors: | A M Felix J W Westley J Meienhofer |
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| Institution: | Chemical Research Department, Hoffmann-La Roche Inc., Nutley, New Jersey 07110 USA |
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| Abstract: | a fluorometric-colorimetric fluorescamine analyzer was successfully utilized for the analysis of a series of actinomycin hydrolysates containing N-methyl-amino acids, proline, and proline derivatives. An explanation is proposed for the low threonine values consistently observed in the analysis of actinomycin hydrolysates and alternate conditions for improved hydrolysis of actinomycins are proposed. |
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