Dissimilar Roles of the Mitochondria in the Modulation of Intracellular Calcium Signals in Primary and Secondary Nociceptive Neurons |
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| Authors: | V Shishkin E Potapenko D Puchkov E Kostyuk N Voitenko P Kostyuk |
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| Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine;(2) International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
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| Abstract: | The role of different Ca2+-regulated mechanisms in the generation of cytosolic Ca2+ transients during neuronal excitation was compared in isolated primary and secondary nociceptive neurons of the rat. Application of carbonyl cyanide m-chlorophenylhydrazone (CCCP) significantly increased the peak amplitude of depolarization-induced transients in dorsal root ganglion (DRG) neurons in contrast to what was observed in spinal dorsal horn (DH) neurons. Application of CCCP immediately after termination of depolarization induced in DRG neurons massive Ca2+ release from the mitochondria into the cytosol. Application of CCCP immediately after termination of depolarization elicited a small Ca2+ release in DH neurons, which became more intense when application of the agent was delayed. |
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| Keywords: | neurons mitochondria calcium |
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