Control of electron transfer in DNA by peptide nucleic acids (PNA). |
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| Authors: | K Tanabe K Yoshida C Dohno A Okamoto I Saito |
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| Affiliation: | Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan. |
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| Abstract: | The one-electron oxidation of PNA-DNA hybrid containing G-triplet sequence was examined. In DNA duplex G-triplet was selectively cleaved by oxidation, whereas in PNA-DNA hybrid cleavage efficiency was extremely lowered. These result suggested that cleavage efficiency of PNA-DNA hybrid was different from that of B-form DNA duplex. |
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