| 降低外淋巴钙浓度对耳蜗电位的影响 |
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| 引用本文： | 王坚,董维嘉,陈继生,刘建瓴.降低外淋巴钙浓度对耳蜗电位的影响[J].生理学报,1994(4). |
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| 作者姓名： | 王坚 董维嘉 陈继生 刘建瓴 |
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| 作者单位： | 南京铁道医学院听觉生理研究室 |
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| 摘 要： | 本实验在人工灌流条件下降低鼓阶外淋巴钙的浓度，观察其对听神经动作电位（ＣＡＰ）、耳蜗微音器电位（ＣＭ）以及蜗内直流电位（ＥＰ）的影响，以分析钙离子的作用机制。无钙液鼓阶灌流使ＣＡＰ、ＣＭ幅度可逆地下降，但不明显地改变ＣＡＰＩ／Ｏ曲线的非线性特征。无钙外淋巴灌流并不改变ＥＰ以及用缺氧法得到的负相ＥＰ（Ｎ－ＥＰ），但使ＥＰ对强声给－撤时的快速变化趋于消失。本文讨论了这些耳蜗生物电改变所提示的钙离子作用的可能机制。
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| 关 键 词： | 钙离子 耳蜗电图 蜗内直流电位 外淋巴灌流 |
EFFECTS OF LOWING PERILYMPH CALCIUM CONCENTRATION ON VARIOUS COCHLEAR POTENTIALS |
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| WANG JIAN,DONG WEI-JIA,CHEN JI-SHENG AND LIU JIAN-LING.EFFECTS OF LOWING PERILYMPH CALCIUM CONCENTRATION ON VARIOUS COCHLEAR POTENTIALS[J].Acta Physiologica Sinica,1994(4). |
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| Authors: | WANG JIAN DONG WEI-JIA CHEN JI-SHENG AND LIU JIAN-LING |
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| Abstract: | In the present experiment, changes in compound action potentials of auditory nerve (CAP),cochlear microphonics (CM) and endocochlear potentials were observed when the calcium concentration of Perilymph was reduced by means of perilymph perfusion, with the aim of analyzing how calcium was involved. Perfusion with Ca2+-free artificial Perilymph reversibly suppressed both CAP and CM amplitudes,but did not alter the basic nonlinear propertres of CAP I/O curve. Furthermore,the perfusion did not altar the EP and negative EP (n-EP) induced by anoxia but eliminated the fast change of EP with respect to turning on and off of intense sound. The mechanisms underlying the effects of calcium are discussed. |
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| Keywords: | calcium ECochG endocochlear potential perilymph perfusion |
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