首页 | 本学科首页   官方微博 | 高级检索  
     


Phosphorylation of nuclear protein is an early event in TGF beta 1 action.
Authors:I M Kramer  I Koornneef  C de Vries  R P de Groot  S W de Laat  A J van den Eijnden-van Raaij  W Kruijer
Affiliation:Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht.
Abstract:Transforming growth factor beta (TGF beta) is a family of polypeptides that modulate growth and differentiation. TGF beta exerts its effects on target cells through interaction with specific cell surface receptors, but the signal transduction pathways are as yet largely unresolved. In this study we report that the growth inhibitory action of TGF beta on mink lung CCl 64 cells is associated with a rapid and transient phosphorylation of a number of nuclear proteins. In parallel, a transient expression of the immediate early gene jun B is observed. The expression of jun B can be inhibited by the protein kinase inhibitor H7 and can be augmented by the phosphatase inhibitor okadaic acid. Thus, protein phosphorylation can be a possible mechanism through which TGF beta 1 initiates early genomic responses.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号