| 2019冠状病毒病对肺外系统的影响及可能机制探讨 |
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| 引用本文： | 许琼 秦慧. 2019冠状病毒病对肺外系统的影响及可能机制探讨[J]. 微生物与感染, 2020, 15(6): 413-420. DOI: 10.3969/j.issn.1673-6184.2020.06.012 |
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| 作者姓名： | 许琼 秦慧 |
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| 作者单位： | 上海交通大学医学院附属仁济医院呼吸科， 上海 200127 |
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| 摘 要： | 2019冠状病毒病(coronavirus disease 2019，COVID-19)是由严重急性呼吸综合征冠状病毒2 (severe acute respiratory syndrome coronavirus 2，SARS-CoV-2)导致的感染性疾病。SARS-CoV-2感染人体后除作用于肺部的SARS-CoV-2功能受体外，还可以作用于心脏、消化道、肝脏、肾脏、中枢系统的SARS-CoV-2功能受体，引起肺外脏器的损伤，诱发多器官功能衰竭，增加COVID-19的病死率。但目前对SARS-CoV-2引起肺外各脏器损伤的具体作用机制还不是很清楚，需要更多临床和实验室数据支持。通过检索COVID-19相关的文献，对SARS-CoV-2导致的肺外系统影响及其可能作用机制作一综述。
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| 关 键 词： | 2019冠状病毒病 严重急性呼吸综合征冠状病毒2 肺外系统损伤 损伤机制 |
Extrapulmonary impairments in COVID-19 patients and the potential mechanisms |
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| XU Qiong,QIN Hui. Extrapulmonary impairments in COVID-19 patients and the potential mechanisms[J]. Journal of Microbes and Infection, 2020, 15(6): 413-420. DOI: 10.3969/j.issn.1673-6184.2020.06.012 |
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| Authors: | XU Qiong QIN Hui |
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| Affiliation: | Department of Respiratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China |
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| Abstract: | Coronavirus disease 19 (COVID-19) related studies that were published on journals and medRxiv were reviewed to explore effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on extrapulmonary organs and its potential mechanisms. In addition to respiratory organs, the expression of SARS-CoV-2 functional receptor has also been observed in human hearts, gut, liver, kidneys, and central nervous systems. The action of SARS-CoV-2 on extrapulmonary receptors may contribute to multiple organ dysfunction and the high mortality rate of COVID-19. However, the exact mechanism leading to extrapulmonary impairments in COVID-19 patients remains elusive and further research is needed to provide more evidence. |
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| Keywords: | Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Extrapulmonary impairment Mechanism |
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