The effect of inbreeding on aggregation of complex diseases in genetic isolates |
| |
Authors: | O A Bulayev T A Pavlova K B Bulayeva |
| |
Institution: | 1.Vavilov’s Institute of General Genetics,Russian Academy of Sciences,Moscow,Russia |
| |
Abstract: | We have studied the effect of genetic processes in ethnically and demographically diverse isolates on the epidemiology of
complex diseases. Our long-term studies of five indigenous Dagestan ethnic groups have revealed ten genetic isolates with
aggregation of schizophrenia-related diseases. According to Neel’s classification (1992), these isolates belong to primary
and secondary depending on the duration of demographic process. We have found that the average demographic ages of the examined
primary and secondary isolates were about 4000 and 700 years, respectively. The inbreeding level F was studied using two methods: analysis of marriage structure in three generations, which is traditional in population-genetic
studies, and analysis of the same structure in extensive pedigrees (up to 11–13 generations). We have shown that with the
second method, the F value increases two- to threefold in various isolates. The accumulated inbreeding in the primary isolates proved to be twofold
higher than that in the secondary ones. Primary isolates have revealed relatively higher genetic and clinical homogeneity
in combination with higher aggregation of population-specific complex disease pathology compared to secondary isolates. A
decrease in observed recombinations and the number of genomic loci linked with the disease in primary isolates have been also
demonstrated. Thus, our studies showed that complex diseases can be less expensive and mapping of genes for time-consuming
if conducted in primary rather than in secondary isolates, in particular when dealing with genetically heterogeneous outbred
human populations. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|