Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis |
| |
| Authors: | Perez-Meseguer Jonathan Del Olmo Esther Alanis-Garza Blanca Escarcena Ricardo Garza-González Elvira Salazar-Aranda Ricardo Feliciano Arturo San de Torres Noemí Waksman |
| |
| Affiliation: | Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico. |
| |
| Abstract: | Twenty-five derivatives of the natural diterpene leubethanol, including several potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Several compounds showed antimycobacterial potencies similar to that of the lead compound and two of them displayed higher selectivity indexes. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
