Adrenergic receptors on cerebral microvessels in control and parkinsonian subjects |
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| Authors: | R Cash F Lasbennes R Sercombe J Seylaz Y Agid |
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| Affiliation: | 1. Laboratoire de Médecine Expérimentale C.H.U. Pitié-Salpêtrière - 91, Bd de l''Hôpital 75634 Paris Cedex 13, France;1. Laboratoire de Physiologie cérébro-vasculaire Unité 182 de l''INSERM - 10, Avenue de Verdun 75010 Paris, France |
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| Abstract: | The binding of adrenergic ligands (3H-prazosin, 3H-clonidine, 3H-dihydroalprenolol) was studied on a preparation of cerebral microvessels in the prefrontal cortex and putamen of control and Parkinsonian subjects. The adrenergic receptor density in microvessels of control patients was less than 0.5% and 3.3% respectively of the total binding. A significant decrease in the number of alpha-1 binding sites was observed on microvessels in the putamen of patients with Parkinson's disease. |
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