Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia |
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| Authors: | Chen Jianchao Tian Renrong Qiu Minghua Lu Lu Zheng Yongtang Zhang Zhongquan |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China. |
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| Abstract: | Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3beta,7beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3beta,25-dihydroxy-5beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 microg/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50)>200 microg/ml), with a selectivity index more than 23.68 and 7.81, respectively. |
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| Keywords: | Momordica charantia Cucurbitaceae Roots Kuguacins A-E Trinorcucurbitane triterpenoids Anti-HIV-1 |
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