Emergence of biofilm-forming subpopulations upon exposure of Escherichia coli to environmental bacteriophages |
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Authors: | Lacqua Andrea Wanner Oskar Colangelo Teresa Martinotti Maria Giovanna Landini Paolo |
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Affiliation: | Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences, University of Eastern Piedmont, A. Avogadro, Via Bovio 6, Novara 28100, Italy. |
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Abstract: | Exposure of Escherichia coli MG1655 to environmental bacteriophages results in rapid selection for phage-tolerant subpopulations displaying increased biofilm formation. Analysis of one phage-tolerant strain revealed large amounts of the DNA-binding Dps protein in the outer membrane protein and production of fimbria-like structures. In dps and fimA mutant derivatives of MG1655, no selection of phage-tolerant bacteria upon exposure to bacteriophages occurred, suggesting a role for Dps and type I pili in bacteriophage tolerance. |
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