首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes
Authors:Chowdhury T T  Bader D L  Lee D A
Institution:Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK. T.T.Chowdhury@qmul.ac.uk
Abstract:Mechanical loading can counteract inflammatory pathways induced by IL-1beta by inhibiting *NO and PGE2, catabolic mediators known to be involved in cartilage degradation. The current study investigates the potential of dynamic compression, in combination with the anti-inflammatory cytokine, IL-4, to further abrogate the IL-1beta induced effects. The data presented demonstrate that IL-4 alone can inhibit nitrite release in the presence and absence of IL-1beta and partially reverse the IL-1beta induced PGE2 release. When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release. IL-1beta inhibited 3H]thymidine incorporation and this effect could be reversed by IL-4 or dynamic strain alone or both in combination. By contrast, 35SO4 incorporation was not influenced by IL-4 and/or dynamic strain in IL-1beta stimulated constructs. IL-4 and mechanical loading may therefore provide a potential protective mechanism for cartilage destruction as observed in OA.
Keywords:IL-4  IL-1β  radical dotels-cdn  NO" target="_blank">com/sd/entities/rad" class="glyphImg">NO  PGE2  Mechanotransduction  Dynamic compression  Anti-inflammatory  Osteoarthritis
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号