GH-dependency of lymphocyte multiplication factor with a low molecular weight |
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| Authors: | R M Schimpff A M Repellin M Bozzola |
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| Affiliation: | I.N.S.E.R.M. H?pital Saint-Vincent-de-Paul, Paris. |
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| Abstract: | Liquid chromatography (FPLC) separation at pH 6.85 shows that the fractions in human serum which stimulate the multiplication of human lymphocyte are mainly in the 28-42 kd and the 1.3-1.9 kd fractions. The low molecular weight fraction is absent or very low in both GH-deficient and GH-resistant children and T lymphocyte-deficient children, and appears after appropriate treatment, i.e. GH or marrow transplantation. The data suggest the GH-dependency of 1.3-1.9 kd factor(s) produced by immuno-competent lymphocytes. |
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