Efficient tumor cell lysis mediated by a Bcl-X(L) specific T cell clone isolated from a breast cancer patient |
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Authors: | Rikke Bæk Sørensen Sine Reker Hadrup Tania Køllgaard Inge Marie Svane Per thor Straten Mads Hald Andersen |
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Institution: | (1) Tumor Immunology Group, Institute of Cancer Biology, Danish Cancer Society, 2100, Strandboulevarden 49, Copenhagen, Denmark;(2) Department of Oncology/Hematology, Herlev University Hospital, 2100 Copenhagen, Denmark |
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Abstract: | Based on the detection of spontaneous immune responses in cancer patients with cancer of different origin, Bcl-X(L) was recently
described as a highly interesting tumor antigen recognized by CD8 positive cytotoxic T lymphocytes. To further characterize
Bcl-X(L) as a tumor antigen we isolated and expanded Bcl-X(L) specific T cells from the peripheral blood of a breast cancer
patient hosting a strong Bcl-X(L) specific T cell response. We describe that HLA-A2 restricted Bcl-X(L) specific T cell clones
very efficiently lyse peptide pulsed T2 cells. Furthermore, tumor cell lines of different origin, i.e., breast cancer, colon
cancer, and melanoma, are efficiently lysed in an HLA-dependent manner. Finally, ex vivo-isolated leukemia cells, but not
non-malignant B and T cells are killed by Bcl-X(L) specific T cells. Our data underline Bcl-X(L) as an universal tumor antigen
widely applicable in specific anticancer immunotherapy. |
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