| MAPK信号转导通路对炎症反应的调控 |
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| 引用本文： | 姜勇,龚小卫.MAPK信号转导通路对炎症反应的调控[J].生理学报,2000,52(4). |
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| 作者姓名： | 姜勇 龚小卫 |
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| 作者单位： | 第一军医大学病理生理教研室暨全军休克微循环重点实验室,广州,510515 |
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| 基金项目： | ThisstudywesupportedbyNationalScienceFundforDistinguishedYoungScholars(No.39925014)，GrantdofNationalNaturalScienceFoundation
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| 摘 要： | 丝裂原活化蛋白激酶 (mitogen -activatedproteinkinase ,MAPK)是生物体内重要的信号转导系统之一 ,参与介导生长、发育、分裂、分化、死亡以及细胞间的功能同步等多种细胞过程。在哺乳动物细胞中已发现和克隆了ERKJNK/SAPK、p38/RK、ERK5/BMK1四个MAPK亚族。这些MAPK能被多种炎性刺激所激活 ,并对炎症的发生、发展起重要调控作用。研究感染和炎症反应过程中这些MAPK被激活的机制及其生物学效应 ,探讨MAPK特异性抑制剂的药理学作用及分子基础 ,对于感染的防治及炎症反应的控制有着广泛的应用前景。
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| 关 键 词： | 丝裂原活化蛋白激酶 信号转导 炎症反应 |
Regulation of inflammatory responses by MAPK signal transduction pathways |
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| JIANG Yong,GONG Xiao-Wei.Regulation of inflammatory responses by MAPK signal transduction pathways[J].Acta Physiologica Sinica,2000,52(4). |
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| Authors: | JIANG Yong GONG Xiao-Wei |
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| Abstract: | Mitogen -activatedproteinkinase(MAPK),whichisone of theimportant sign altrans duction sys tem sinorganisms,isinvolvedinmanycellularprocesses,suchascellgrowth,development,division,differentia tion,deathandcoordinationofcellularfunctions,andetc.FoursubfamiliesofMAPkinases,i.e.ERK, JNK/SAPK,p38/RKandERK5/BMK1,havebeenidentifiedandclonedinmammaliamcells.TheseMAPkinas esareactivatedbymanyproinflammatorystimuliandplayanimportantroleinthepathogenesisanddevelop mentofinflammation.Inthisarticlerecentadvancesinthestudyofthemechanismsunderlyingactivationof MAPKsininfectionandinflammationandthemolecularbasisofspecificinhibitorsforMAPKsarereviewed,in specialreferencewiththeperspectivepreventionandtreatment of inflammation by the sekinases. |
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| Keywords: | mitogen -activated proteinkinase signal transduction inflammatory responses |
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