Phospholipids and lipid droplets |
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Authors: | Anke Penno Gregor Hackenbroich Christoph Thiele |
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Affiliation: | 1. Life and Medical Sciences (LIMES) Institute, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany;2. SAP Research Dresden, SAP AG, Chemnitzer Strasse 48, 01187 Dresden, Germany |
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Abstract: | Lipid droplets are ubiquitous cellular organelles that allow cells to store large amounts of neutral lipids for membrane synthesis and energy supply in times of starvation. Compared to other cellular organelles, lipid droplets are structurally unique as they are made of a hydrophobic core of neutral lipids and are separated to the cytosol only by a surrounding phospholipid monolayer. This phospholipid monolayer consists of over a hundred different phospholipid molecular species of which phosphatidylcholine is the most abundant lipid class. However, lipid droplets lack some indispensable activities of the phosphatidylcholine biogenic pathways suggesting that they partially depend on other organelles for phosphatidylcholine synthesis. |
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Keywords: | Lipid droplet Phosphatidylcholine Steatosis |
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