Adenosine A2A receptor activation supports an atheroprotective cholesterol balance in human macrophages and endothelial cells |
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| Authors: | Iryna Voloshyna Steven Carsons Michael J. Littlefield Jayson M. Rieger Robert Figler Allison B. Reiss |
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| Affiliation: | 1. Winthrop Research Institute, Department of Medicine, Winthrop University Hospital, 222 Station Plaza North, Suite 511B, Mineola, NY 11501, USA;2. Trovis Pharmaceuticals LLC, a subsidiary of Clinical Data, Inc., 310 4th St. NE, Suite 201, Charlottesville, VA 22902, USA |
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| Abstract: | The adenosine A2A receptor (A2AR) plays an important role in the regulation of inflammatory and immune responses. Our previous work has demonstrated that A2AR agonists exhibit atheroprotective effects by increasing expression of reverse cholesterol transport proteins in cultured human macrophages. This study explores the impact of pharmacologic activation/inhibition and gene silencing of A2AR on cholesterol homeostasis in both THP-1 human monocytes/macrophages and primary human aortic endothelial cells (HAEC). |
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| Keywords: | A2AR, adenosine 2A receptor ABC transporters, ATP-binding cassette transporters CD36, cluster of differentiation 36 FCF, foam cell formation LDL, low-density lipoprotein LOX-1, the lectin-like oxidized low-density lipoprotein receptor PMA, Phorbol 12-myristate 13-acetate SR-AI, scavenger receptor class A type I |
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