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DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux—An LXR-dependent mechanism |
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| Authors: | Ling Zhang Meixiu Jiang Yongsheng Shui Yuanli Chen Qixue Wang Wenquan Hu Xingzhe Ma Xiaoju Li Xin Liu Xingyue Cao Mengyang Liu Yajun Duan Jihong Han |
| Institution: | 1. State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center o Biotherapy, Nankai University, Tianjin 300071, China;2. College of Life Sciences, Nankai University, Tianjin 300071, China;3. Medical College of Wisconsin, Milwaukee, WI 53226, USA;4. University of Notre Dame, Notre Dame, IN 46556, USA |
| Abstract: | |
| Keywords: | ABCA1 ATP-binding cassette transporter A1 ABCG1 ATP-binding cassette transporter G1 apoAI apolipoprotein AI FAS fatty acid synthase HDL high-density lipoprotein LXR liver X receptor LXRE LXR responsive element RIP140 receptor-interacting protein 140 RXR retinoid X receptor Topo II DNA topoisomerase II |
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