The ins and outs of phosphatidylethanolamine synthesis in Trypanosoma brucei |
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Authors: | Luce Farine,Peter Bü tikofer |
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Affiliation: | Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland |
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Abstract: | Phospholipids are not only major building blocks of biological membranes but fulfill a wide range of critical functions that are often widely unrecognized. In this review, we focus on phosphatidylethanolamine, a major glycerophospholipid class in eukaryotes and bacteria, which is involved in many unexpected biological processes. We describe (i) the ins, i.e. the substrate sources and biochemical reactions involved in phosphatidylethanolamine synthesis, and (ii) the outs, i.e. the different roles of phosphatidylethanolamine and its involvement in various cellular events. We discuss how the protozoan parasite, Trypanosoma brucei, has contributed and may contribute in the future as eukaryotic model organism to our understanding of phosphatidylethanolamine homeostasis. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism. |
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Keywords: | PE, phosphatidylethanolamine PC, phosphatidylcholine PS, phosphatidylserine PI, phosphatidylinositol SM, sphingomyelin IPC, inositolphosphoryl ceramide EPC, ethanolaminephosphoryl ceramide EPT, ethanolamine phosphotransferase CEPT, choline/ethanolamine phosphotransferase PSD, PS decarboxylase NAE, N-acylethanolamine GPI, glycosylphosphatidylinositol eEF1A, eukaryotic elongation factor 1A EPG, ethanolamine phosphoglycerol LPS, lipopolysaccharide DAG, diacylglycerol AAG, alk-1-enyl-acylglycerol |
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