| 病原性真菌蛋白酶致病机制研究进展 |
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| 引用本文： | 桑军军,李颖芳,潘炜华,廖万清.病原性真菌蛋白酶致病机制研究进展[J].微生物与感染,2017,12(1):8-13. |
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| 作者姓名： | 桑军军 李颖芳 潘炜华 廖万清 |
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| 作者单位： | 上海长征医院皮肤病与真菌病研究所，上海市医学真菌分子生物学重点实验室，全军真菌与真菌病重点实验室，第二军医大学附属长征医院皮肤科，上海 200003 |
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| 基金项目： | 国家重点基础研究发展计划(2013CB531601);上海市医学真菌分子生物学实验室基金 |
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| 摘 要： | 蛋白酶在真菌的生存和生长过程中具有重要作用，同时也被认为是病原真菌重要的毒力因子之一。病原真菌的蛋白酶可能参与真菌在宿主的黏附、定植和播散以及逃避宿主的免疫应答过程。部分蛋白酶还被认为是变应原，可诱发哮喘和过敏性疾病。在不同的病原真菌中，蛋白酶作用也不同。研究蛋白酶的致病机制，可进一步了解真菌感染机制，为诊断及治疗真菌感染提供线索。
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| 关 键 词： | 病原真菌 蛋白酶 致病机制 真菌感染 |
The pathogenetic mechanism of proteases from pathogenic fungi |
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| SANG Junjun,LI Yingfang,PAN Weihua,LIAO Wanqing.The pathogenetic mechanism of proteases from pathogenic fungi[J].Journal of Microbes and Infection,2017,12(1):8-13. |
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| Authors: | SANG Junjun LI Yingfang PAN Weihua LIAO Wanqing |
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| Institution: | Institute of Dermatology and Mycoses, Shanghai Key Laboratory of Medical Molecular Mycology, Key Laboratory of Fungal Diseases, Department of Dermatology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China |
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| Abstract: | Proteases play an important role in fungal physiology and growth and in infection of pathogenic fungi as well .Fungal proteases may be involved in adhesion ,colonization ,spreading and escaping from the host immune response .Some proteases are considered as allergens ,which can induce asthma and allergic diseases .Knowledge of the pathogenesis of the proteases will increase our understanding about the action of each fungal protease and will help to provide clues for the diagnosis and treatment of fungal infection . |
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| Keywords: | Pathogenic fungus Protease Pathogenetic mechanism Fungal infection |
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