Novel oxindole derivatives and their biological activity |
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| Authors: | J Strigácová D Hudecová M Mikulášová L' Varečka A Lásiková D Végh |
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| Institution: | (1) Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia;(2) Department of Organic Chemistry, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia |
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| Abstract: | The antifungal activity of fourteen novel derivatives of oxindole with side chain was studied using representatives of toxinogenic,
phytopathogenic and dermatophytic filamentous fungi. Derivatives with exocyclic C=C bond in position C-3 exhibited a higher
antifungal activity compared with derivatives with an exocyclic C−C bond in the same position. The strongest antifungal effects
were shown by 3-(-2-thienoylmethylidene)-indol-2(3H)-ones. |
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