A mitochondrial ribosomal RNA mutation and its nuclear suppressors |
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Authors: | V Contamine and M Bolotin-Fukuhara |
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Institution: | (1) Laboratoire de Biologie Générale, Université de Paris-Sud, Centre d'Orsay, Bâtiment 400, F-91405 Orsay Cedex, France;(2) c/o Prof. M. Nomura, Institute for Enzyme Research, University of Wisconsin, 53706 Madison, Wisconsin, USA |
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Abstract: | Summary We have isolated cold-resistant revertants from a mitochondrial cold-sensitive mutation, cs909, localized in the 21S ribosomal RNA gene.Two types of revertants have been isolated: (1) strong revertants which were shown to be due to a single, nuclear, dominant suppressor; (2) weak revertants which are all due to the presence of a single, nuclear, recessive suppressor.The recessive suppressor, when separated from the mitochondrial mutation, itself confers a cold-sensitive phenotype, that is, there is a mutual suppression between the mitochondrial cold-sensitive mutation and the nuclear cold-sensitive mutation. The suppressor by itself produces modified ribosomes and therefore probably codes for an element of the mitochondrial ribosome such as a ribosomal protein. |
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