Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production |
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Authors: | Youn-Young Kim Song-Hee Kim Sora Oh Ok-Joo Sul Hye-Young Lee Hyun-Ju Kim Shin-Yoon Kim Hye-Seon Choi |
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Affiliation: | 2. Department of Biological Sciences (Brain Korea 21 Program) and the Immunomodulation Research Center, University of Ulsan, Ulsan, 680-749, Korea 1. Skeletal Diseases Genome Research Center, School of Medicine, Kyungpook National University, Daegu, 700-412, Korea
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Abstract: | Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat. We observed elevated osteoclast (OC) formation by bone marrow-derived macrophages treated with medium conditioned by fats from OVX mice, but not from sham-operated mice. Fats from OVX mice expressed and secreted higher levels of monocyte chemoattractant protein-1 (MCP-1) than those from sham-operated mice. Increased fat resulting from estrogen deficiency is thus responsible for bone loss due to enhanced OC formation, which is, at least partly, a consequence of elevated MCP-1 production. |
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