Glycosylation and production characteristics of epothilones in alkali-tolerant Sorangium cellulosum strain So0157-2 |
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| Authors: | Lin Zhao Peng-fei Li Chun-hua Lu Shu-guang Li Yue-mao Shen Yue-zhong Li |
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| Affiliation: | (1) State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, 250100, P. R. China;(2) Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, Fujian Laboratory of Pharmaceutical Engineering, School of Life Science, Xiamen University, Xiamen, Fujian, 361005, P. R. China; |
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| Abstract: | 3-O-α-D-ribofuranosyl epothilone A (epothiloneoside A) is a major component of glycosylated epothilones in Sorangium cellulosum strain So0157-2. The production and glycosylation ratios of epothiloneoside A in both solid and liquid culture conditions with various pH values and carbon sources were studied. The results showed that glycosylation occurs whenever epothilones are produced, regardless of changes in pH values, production time curves, and different carbon sources. We suggest that glycosylation is a stable process, paralleling the biosynthesis of epothilones in the So0157-2 strain. |
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