Effects of a synbiotic product on blood antioxidative activity in subjects colonized with Helicobacter pylori |
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Authors: | P Hütt H Andreson T Kullisaar T Vihalemm E Unt J Kals P Kampus M Zilmer M Mikelsaar |
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Institution: | Department of Microbiology, Medical Faculty, University of Tartu, Tartu, Estonia; Department of Biochemistry, Medical Faculty, University of Tartu, Tartu, Estonia; Institute of Exercise Biology and Physiotherapy, University of Tartu, Tartu, Estonia; Department of Cardiology, Medical Faculty, University of Tartu, Tartu, Estonia |
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Abstract: | Aim: To evaluate the impact of the consumption of a synbiotic product on the antioxidative activity markers of blood in asymptomatic H. pylori -colonized persons. Methods and Results: Fifty-three healthy adult volunteers without gastric symptoms participated in a randomized, double-blind placebo-controlled study. The crossover consumption of the enterocoated capsules containing antioxidative Lactobacillus fermentum ME-3, Lact. paracasei 8700:2 and Bifidobacterium longum 46 with Raftilose P95 lasted for 3 weeks and did not change the H. pylori colonization. In H. pylori -positive subjects the sera values of total antioxidative status (TAS) were significantly lower compared to H. pylori -negative subjects (0·97 vs 1·05 mmol l−1, P = 0·008). After the consumption of the synbiotic, TAS values (0·97 vs 1·03 mmol l−1, P = 0·004) increased, while the ratio between oxidized and reduced glutathione (0·035 vs 0·030, P = 0·016) decreased in H. pylori -positive subjects. Conclusions: The consumption of a synbiotic containing an antioxidative probiotic strain improved the reduced systemic antioxidative activity in H. pylori -colonized asymptomatic subjects. Significance and Impact of the Study: A synbiotic product containing an antioxidative probiotic strain may be useful in the reduction of systemic oxidative stress in H. pylori infection. |
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Keywords: | blood antioxidative activity H pylori colonization synbiotic |
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