Enhanced Expressions of Arginine Vasopressin (Avp) in the Hypothalamic Paraventricular and Supraoptic Nuclei of Type 2 Diabetic Rats |
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Authors: | Sun Shin Yi In Koo Hwang Yo Na Kim Il Yong Kim Son-Il Pak In Se Lee Je Kyung Seong Yeo Sung Yoon |
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Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Laboratory of Veterinary Clinical Pathology & Epidemiology, School of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea |
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Abstract: | Arginine vasopressin (AVP) is known to a neuropeptide that plays important roles in water conservation, sodium homeostasis,
and in the regulation of serum osmolality. Several studies have reported that the elevated AVP level is related with diabetes
mellitus as an acute or chronic stressor using type 1 diabetes mellitus animal models. However, it is unclear as to how the
immunoreactivity and protein level of AVP in the brain is regulated in animal models of type 2 diabetes mellitus. In the present
study, Zucker diabetic fatty (ZDF) rats were employed as a type 2 diabetes mellitus model and were compared with Zucker lean
control (ZLC) rats with respect to AVP protein expression. Furthermore, in order to verify the regulation of AVP expression
before and after the onset of diabetes mellitus, pre-diabetic rats (4 week-old) and obese-diabetic rats (12 week-old) were
used. Blood glucose levels and water consumption were also measured and the results showed significantly high in 12 week-old
ZDF than any other groups. AVP expression levels in the paraventricular nucleus and supraoptic nucleus were found to be significantly
higher in 12 week-old ZDF rats than in 12 week-old ZLC rats and than in 4 week-old rats by immunostaining and western blotting.
Enhanced expression of AVP in these animals may be associated with type 2 diabetes mellitus.
Special issue article in honor of George Fink. |
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Keywords: | Type 2 diabetes Paraventricular nucleus Supraoptic nucleus Zucker rat Arginine vasopressin |
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