苏木提取物抗肿瘤作用的研究进展

中医认为恶性肿瘤发展的后期需要进行活血化瘀治疗。苏木(CAE)为豆科云实属植物的干燥心材,具有行血祛瘀、消肿止痛的功效。近年来研究证实,苏木提取物不仅可以抑制肿瘤细胞的增殖、侵袭和转移,促进肿瘤细胞凋亡,而且能够抑制肿瘤血管生成因子的信号传导途径,从而抑制肿瘤新生血管的生成。苏木提取物在多系统中发挥着不同机制的抗肿瘤作用。本文就苏木提取物在抗肿瘤治疗中的研究进展作一综述。

Study on Anti-tumor Effects of the Extracte from Caesalpinia Sappan L

Traditional Chinese medicine (TCM) holds that the development of malignant tumors need to promoting blood circulation.Caesalpinia Sappan L is a plant of sappanwood dry heartwood which has the effect of dispelling blood stasis and swelling andpain. The recent studies have showed that the Caesalpinia Sappan L can inhibit the proliferation, invasion and metastasis of tumor cells,and promote tumor cell apoptosis, as well as signal pathways in inhibiting tumor angiogenesis factor in order to inhibite the generation oftumor angiogenesis. Caesalpinia Sappan L extracted in multiple systems with different mechanisms of antitumor effect. In this paper, theresearch progress of Caesalpinia Sappan L in anti-tumortherapy was reviewed.