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Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones |
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| Authors: | Hutchings Kim M Tran Tuan P Ellsworth Edmund L Watson Brian M Sanchez Joseph P Hollis Showalter H D Stier Michael A Shapiro Martin Themis Joannides E Huband Michael Nguyen Dai Q Maiti Samarendra Li Tingsheng Tailor Jyoti Thomas George Ha Chan Singh Rajeshwar |
| Affiliation: | Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor Campus, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. kim.hutchings@astrazeneca.com |
| Abstract: | A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported. |
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