Analgesic activity of enkephalins following intracerebral administration in the rat |
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| Authors: | Malick J B Goldstein J M |
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| Affiliation: | Biomedical Research Department, Stuart Pharmaceuticals, Division of ICI United States Inc., Wilmington, DE 19897, USA. |
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| Abstract: | Methionine- and leucine-enkephalin were found to be potent, short-acting analgesics in the tail flick test in rats following intracerebral administration, via chronically indwelling cannulae, into the midbrain periaqueductal gray. Morphine sulfate was approximately 4 times as potent as the enkephalins when infused into this same brain site. The analgesia produced by the enkephalins and by morphine was inhibited by pretreatment with naloxone. |
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