Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents |
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| Authors: | Franck Prugnolle Kate McGee Jon Keebler Philip Awadalla |
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| Institution: | (1) Laboratoire GEMI, UMR 2724 CNRS-IRD, 911 avenue Agropolis, BP 64501, 34394 Montpellier, Cedex 5, France;(2) Department of Genetics, North Carolina State University, PO Box 7614, Raleigh, 27659, USA;(3) Ste Justine Hospital Research Centre, Department of Pediatric, Faculty of Medicine, University of Montreal, Montreal, H3T 1C5, Canada |
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| Abstract: | Background Malaria kills more people worldwide than all inherited human genetic disorders combined. To characterize how the parasites
causing this disease adapt to different host environments, we compared the evolutionary genomics of two distinct groups of
malaria pathogens in order to identify critical properties associated with infection of different hosts: those parasites infecting
hominids (Plasmodium falciparum and P. reichenowi) versus parasites infecting rodent hosts (P. yoelii yoelii, P. berghei, and P. chabaudi). Adaptation by the parasite to its host is likely highly critical to the evolution of these species. |
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