Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110 |
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Authors: | Shin Hee Jae Jeong Hyun Sun Lee Hyi-Seung Park Song-Kyu Kim Hwan Mook Kwon Ho Jeong |
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Affiliation: | Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan, P O. Box 29, Seoul 425-600, Korea. shinhj@kordi.re.kr |
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Abstract: | An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines. |
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