The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis. |
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| Authors: | K Kakimoto T Nakamura K Ishii T Takashi H Iigou H Yagita K Okumura K Onoue |
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| Institution: | Department of Biochemistry, Kumamoto University Medical School, Japan. |
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| Abstract: | In order to study how inflammatory cells including autoimmune lymphocytes interact with each other to develop collagen-induced arthritis (CIA), we injected monoclonal antibodies against mouse LFA-1 and ICAM-1 into DBA/1 mice immunized with type II collagen (CII). Both antibodies suppressed the development of CIA. These antibodies showed no effect on anti-CII antibody response, although they both significantly suppressed DTH response. It was suggested that anti-adhesion molecule antibodies suppress CIA mainly through their effect on cell-mediated immunity, without affecting humoral immunity under the conditions used. |
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