Studies of the mouse Ly-6 alloantigen system |
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| Authors: | Shoji Kimura Nobuhiko Tada Yen Liu-Lam Ulrich Hämmerling |
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| Institution: | (1) Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021 New York, New York;(2) Present address: Dept. of Pathology, Wakayama Medical College, 7-Ban-cho-7, Wakayama, Japan;(3) Present address: Dept. of Pathology, Tokai University School of Medicine, Boseidai, Isehara Kanagawa, Japan |
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| Abstract: | The discovery of several monoclonal antibodies provided the impetus to revisit the Ly-6 group of antigens. Our serological data point to the existence of at least five separate Ly-6 antigens. They are distinguished by the patterns of their tissue expression as (1) the classical Ly-6 alloantigen of peripheral lymphocytes (Ly-m6.2A), (2) a bone marrow cell-restricted antigen (Ly-m6.2B), (3) an antigen shared by bone marrow cells and peripheral lymphocytes (Lym6.2C, possibly identical with H9/25),(4) an antigen expressed on bone marrow cells, thymocytes, and peripheral lymphocytes (Ly-m6.2D), and (5) an antigen occurring exclusively on lymphoblasts (Ly-m6.IE, similar to Ala-1). ThB is a sixth distinct antigen of the group. The assumption that separate antigens exist is supported by distinctive distribution patterns in normal and neoplastic tissues. The genes controlling Ly-6 antigens are closely linked, as they are transmitted as two haplotypes only. One incidence of a crossover within the Ly-6 region was observed: the Ly-6B.2 alloantigen was expressed in NZB mice, which type Ly-6.1 for other Ly-6 specificities. |
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