Turnover of enzymes of peroxisomal β-oxidation in rat liver |
| |
Authors: | Shoko Miyazawa Shuichi Furuta Takashi Osumi Takashi Hashimoto |
| |
Affiliation: | Department of Biochemistry, Faculty of Medicine, Shinshu University, Asahi, Matsumoto, Nagano 390 Japan |
| |
Abstract: | Male Wistar rats were given a diet containing 2% (w/w) di-(2-ethylhexyl)-phthalate (DEHP), a peroxisomal proliferator, for 4 weeks. The activities of enzymes of peroxisomal β-oxidation and of catalase were markedly increased by the DEHP administration. The time required to reach halfway to the maximal induction for enzymes of peroxisomal β-oxidation was 5–7 days, whereas that for catalase was 3 days. A separate DEHP group was placed on the control diet after 14 days of feeding with the DEHP diet. On the withdrawal of DEHP, activities of enzymes of the β-oxidation system and of catalase decreased to the control levels with a half-life of 2–3 days. Responses of some mitochondrial enzymes involved in fatty acid oxidation are also described. |
| |
Keywords: | Peroxisome β-oxidation Enzyme turonver (Rat liver) DEHP di-(2-ethylhexyl)phthalate |
本文献已被 ScienceDirect 等数据库收录! |
|