Platelet factor 4 regulates osteoclastic bone resorption in vitro |
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| Authors: | John E Horton Judith Harper Elvin Harper |
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| Institution: | 1. Department of Periodontology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA;2. Department of Chemistry D-006, University of California at San Diego, La Jolla, CA 92093, U.S.A. |
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| Abstract: | Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption. |
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| Keywords: | Platelet factor 4 Osteoclast Bone resorption Parathyroid hormone |
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