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Resonance electroconformational coupling: A proposed mechanism for energy and signal transductions by membrane proteins |
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| Authors: | Tian Yow Tsong Dao-Sheng Liu Francoise Chauvin R Dean Astumian |
| Institution: | (1) Department of Biological Chemistry, Johns Hopkins University School of Medicine, 21205 Baltimore, Maryland, USA;(2) Laboratory of Biochemistry, National Heart, Lung and Blood Institute, NIH, 20892 Bethesda, Maryland, USA;(3) Present address: Department of Biochemistry, University of Minnesota College of Biological Sciences, 55108 St Paul, Minnesota |
| Abstract: | Recent experiments show that membrane ATPases are capable of absorbing free energy from an applied oscillating electric field and converting it to chemical bond energy of ATP or chemical potential energy of concentration gradients. Presumably these enzymes would also respond to endogenous transmembrane electric fields of similar intensity and waveform. A mechanism is proposed in which energy coupling is achieved via Coulombic interaction of an electric field and the conformational equilibria of an ATPase. Analysis indicates that only an oscillating or fluctuating electric field can be used by an enzyme to drive a chemical reaction away from equilibrium.In vivo, the stationary transmembrane potential of a cell must be modulated to become  locally oscillatory if it is to derive energy and signal transduction processes. |
| Keywords: | energy transduction signal transduction membrane proteins resonance conformation |
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