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Antiplatelet effects of acidamides isolated from the fruits of Piper longum L. |
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| Authors: | B.-S. Park D.-J. Son Y.-H. Park T.W. Kim S.-E. Lee |
| Affiliation: | aInstitute of Ecological Phytochemistry, Hankyong National University, Ansung City, Kyonggi-Do 456-749, Republic of Korea bCollege of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea cCollege of Natural Sciences, Soonchunhyang University, Asan 336-745, Republic of Korea dSchool of Plant Life and Environmental Science, Hankyong National University, Ansung City, Kyonggi-Do 456-749, Republic of Korea eNanotoxtech. Inc., 237 LG Twinhouse, 192 Gumi-dong, Bundang-gu, Seongnam 463-708, Republic of Korea |
| Abstract: | The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF. |
| Keywords: | Antiplatelet activity Piperlongumine Piper longum L. |
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