The proportion of TA, TG, and TM cells in various immunodeficiency and autoimmune disorders |
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| Authors: | L G Lum E Benveniste A D Steinberg T A Waldmann R M Blaese |
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| Institution: | 1. Fred Hutchinson Cancer Research Center and Division of Oncology, Departments of Pediatrics and Medicine, University of Washington School of Medicine, Seattle, Washington 98104 U.S.A.;2. Departments of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los Angeles, California 90024 U.S.A.;3. Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205 U.S.A.;4. Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205 U.S.A. |
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| Abstract: | Patients with various immunodeficiency and autoimmune disorders were examined for the proportions of T cells bearing Fc-IgA, Fc-IgG, and Fc-IgM receptors. These disorders included common variable immunodeficiency, systemic lupus erythematosus, ataxia-telangiectasia, selective IgA deficiency, and the Wiskott-Aldrich syndrome. Abnormal proportions (higher or lower than an interval containing 95% of our normal values) of Fc-IgA receptor-bearing T cells (TA) were found in common variable immunodeficiency, systemic lupus erythematous, ataxia-telangiectasia, and selective IgA deficiency. However, the proportion of T cells bearing Fc receptors did not correlate with their functional activity in in vitro immunoglobulin production assays. |
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| Keywords: | To whom correspondence should be addressed: Fred Hutchinson Cancer Research Center 1124 Columbia Street Seattle Wash 98104 |
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